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Int J Mol Sci 22(13):7048 Mansour M, Mohamed MF, Elhalwagi A, El-Itriby HA, Shawki HH, Abdelhamid IA (2019) Moringa peregrina leaves extracts induce apoptosis and cell cycle arrest of hepatocellular carcinoma
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
Previous publications have demonstrated that oxidative stress significantly decreased SIRT1 activity in previously experimental models
However, the significance of these findings is difficult to assess without a control group for comparison
Moreover, through the modification of tissue targeting groups and microenvironment responsive groups, nanomedicine can respond to the high ROS levels at the oxidative damage site for precise drug delivery, enhancing the therapeutic effect and reducing the side effects [201, 202]
