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Interestingly, the aforementioned autophagy repressing complex SEACIT containing Npr2p also negatively regulates tRNA thiolation [30], Hence interlinking cell growth control and translational capacity to spare sulfur containing amino acids during methionine starvation

2016 doi: 10.1038/nature19079

117 Apolipoprotein E (APOE), particularly the 4 allele, stands out as the most crucial genetic risk factor for SAD