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So far, 22 ADAM genes have been identified in humans but only 12 encode active proteinases

Studies are identifying an increasing number of natural products that downregulate AURKs, and the modification of AURKA inhibitors may be a promising research direction

10.1016/j.bbagen.2013.02.009 51 GopalS.BorovokI.OferA.YankuM.CohenG.GoebelW.et al

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