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Copper accumulation is theoretically possible with long-term, high-dose use, particularly in individuals with genetic copper metabolism disorders like Wilsons diseasethough the copper content in therapeutic GHK-Cu doses is minimal compared to dietary intake

doi:10.1002/ptr.5019 Belcaro G, Cornelli U, Dugall M, Hosoi M, Cotellese R, Feragalli B

Mohamed HY, Ismael E, Elaasser MM, Khalil MM

doi: 10.1021/acssuschemeng.3c03170

In previous study, we demonstrated that matrix stiffness regulates the ability of fibrotic lung myofibroblasts to invade the BM, by increasing 6-expression, mediating MMP-2-dependent pericellular proteolysis of BM collagen IV

10.1515/bc.2000.107 Biol