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Numerous large randomized controlled trials have reported statistically significant reductions in CV events for three of the FDA-approved SGLT2 inhibitors (empagliflozin, canagliflozin, and dapagliflozin) and four FDA-approved GLP-1 receptor agonists (liraglutide, albiglutide [although that agent was removed from the market for business reasons], semaglutide [lower risk of CV events in a moderate-sized clinical trial but one not powered as a CVOT], and dulaglutide)

Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin (GetGoal-S) J Diabetes Complications

This may reflect GIP's distinct receptor pharmacology or tirzepatide's specific molecular design

Ozempic EPAR Public Assessment Report

Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function

Making lists of the conditions you have, medications you take, and doctors you see can help you choose the best plan for your needs