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A similar peroxidase-mediated redox relay has been described for the mammalian Prx1, which accelerates oxidation of the apoptosis signaling kinase 1 (ASK1) via transient formation of a Prx1-ASK1 disulfide [111]

doi: 10.1159/000115365 360 StofkovaA

Building on this trial, the global phase III MIRASOL trial randomized patients with FR-positive, platinum-resistant disease to MIRV versus investigators choice chemotherapyshowing significantly improved PFS, OS, and objective response rate with the ADC [14]

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Kim HK, Nunes PV, Oliveira KC, Young LT, Lafer B

As expected, A aggregates in old nTg neurons were negligible (Fig