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ASH Annu Meet Abstr

RNA content in human lymphocyte subpopulations

GSH and necroptosis Necroptosis is a regulated form of necrotic cell death characterized by activation of RIPK3 and mixed lineage kinase domain-like pseudokinase (MLKL), with receptor-interacting serine/threonine kinase 1 (RIPK1) participating in many, but not all, necroptotic contexts

These manifestations occurred at a mean age of ~60 years, and progressed towards the appearance of a pseudobulbar palsy (a syndrome characterized by slurred speech, dysarthria, dysphagia and emotional lability, which is caused by bilateral lesions of corticobulbar pyramidal tracts), a step-by-step walk (marche petits pas), cognitive decline, dementia and premature death

It does not cause clinically significant changes in blood pressure or prolong the QT interval, meaning it lacks a hypertension warning and can be safely used in patients with pre-existing hypertension (Staskin et al 2024)

Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon pathways