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However, recent simulation studies demonstrate that either dosing method results in a similar degree of PK and PD variability suggesting that normalization of dose by body weight is an unnecessary step.36, 37, 38 Regardless of the option taken, the strategy should provide reduced interpatient variability to optimize therapeutic effect coupled with convenience, compliance, and costeffectiveness

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Kreuz K, Tommasini R, Martinoia E 1996 Old enzymes for a new job: Herbicide detoxification in plants

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Acknowledgements We acknowledge the AAV Core Facility of Academia Sinica for generating recombinant AAV (Grant AS-CFII112-204)

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