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The conversion of DOX to its semiquinone is thought to play an essential role in its nephrotoxic actions[29]

Polar hydrogens including Kollmann charges were added, also Gasteiger charges were computed

Reverse transcription was performed using the All-in-one First-Strand cDNA synthesis kit (Sevenbio, Beijing) for cDNA amplification

75% of blood coming to the liver arrives directly from gastrointestinal organs and the spleen via portal veins that bring drugs and xenobiotics in near-undiluted form

doi: 10.3892/mmr.2021.12463 20 GuBHBaekKH

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