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METABOLIC MODULATORS S4.4.1 Activators of the AMP-activated protein kinase (AMPK), e.g

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A series of recent studies implicated sirtuins as potent negative regulators of fibroblast activation and myofibroblast differentiation, and sirtuin dysfunction has been linked to the pathogenesis of SSc and other fibro-inflammatory conditions 28,29,38,39,40,41,42