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Hepatic SAM acts to fine-tune the catabolic responses to fasting by increasing the activity the PEMT encoded enzyme

Rigorous human pharmacokinetic data do not exist because no completed Phase 1-3 clinical trials have been published

The tumor growth curve in 4T1-tumor bearing mice following various treatments, shown in Fig

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doi: 10.3389/fphar.2025.1660890 Received 08 July 2025 Accepted 04 September 2025 Published 01 October 2025 Volume 16 - 2025 Edited by Sarmistha Saha, GLA University, India Reviewed by Sidharth Mehan, Indo-Soviet Friendship College of Pharmacy, India Pratibha Singh, All India Institute of Medical Sciences, India Updates Copyright 2025 Peng, Meng, Deng, Huang, Mao, Long, Yan, Peng, Wang and Liu