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Driven by the need to estimate internal exposures where in vivo data generation is not possible, alternative testing strategies incorporating in vitro and in silico human specific models have recently gained interest

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Appetite and satiety regulation reduces caloric intake without the metabolic adaptation seen in caloric restriction alone

is supported by the NIH/NCI (DP2 OD024174-01), NIH/NIDDK (R01 DK123323-01), Pershing Square Sohn Foundation and Mark Foundation Emerging Leader Award