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(65) demonstrated an improvement in insulin sensitivity and a reduction in serum insulin levels in diabetic patients consecutively taking clopidogrel and oral hypoglycaemic agent after 2 months of therapy

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Based on the existing literature, we hypothesize how the endocannabinoid system interacts with the monoaminergic and glutamatergic systems, its impact on the HPA axis, and how these interactions may ultimately influence P450 enzyme expression