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Salamanca, Spain), AFIBROSE (Asociacin de Fibromialgia de Sevilla

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Chemical and instrumental approaches to treat hyperpigmentation

9 Long-term side effects Regular use may eventually cause: rapid or irregular heartbeat, high blood pressure and potential inflammation of heart valves skin disorders, vitamin deficiency, flushed or pale skin stomach ulcers and malnutrition mental health and behavioural problems dizziness and difficulty breathing loss of coordination and physical collapse unusual tiredness or weakness repetitive physical actions convulsions, coma, and death

doi: 10.1016/S0031-9422(97)00211-2

Laboratory studies have also examined its proposed role in modulating gene expression, circadian and pineal regulatory pathways, oxidative-stress responses, and the development of spontaneous tumors in rodent models