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and (3) pain defined as distal extremity pain plus one of the following: dysesthesia, burning/painful feet worsening at night or intolerance of sheets/clothes touching the legs or feet

Solution of the DORP The fundamentals of optimal control theory include Pontryagins Minimum Principle, Canonical Hamiltonian Equations, and Riccati Equations

Availability: You can find it online through various retailers and possibly through clinics in Bangladesh

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The primary consideration for extended use is whether the therapeutic goal tissue repair, metabolic optimization has been achieved, or whether ongoing use serves a maintenance function