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Despite the efficacy of current antiepileptic drugs, almost 30% of patients with epilepsy are refractory to medical treatment, have progressive cognitive impairment, and require neurosurgical resection of the epileptic tissue to ameliorate recurring seizures (Laxer et al., 2014)

As we have seen throughout this section, although it is clear that sex steroids play a more than important role in the control of GH secretion, with E2 as the main actor, there are many controversies regarding both the mechanism of action and the effects they produce
The hypothalamic-pituitary-adrenal and the GH/IGF-I axis are also closely associated, as cortisol is required for physiological GH secretion
