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In the investigation of KRAS/LKB1/KEAP1 mutant lung adenocarcinoma cells, mild oxidative stress was observed to decrease NRF2 SUMOylation, which in turn enhanced the migration and invasion of these cells [132]
The Physics of Cancer: The Role of Physical Interactions and Mechanical Forces in Metastasis
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showed that, acidic extracellular microenvironment enhances the invasiveness of prostate cancer PC-3 cells by upregulating the secretion of cathepsin B, a protease involved in extracellular matrix degradation (75)
Cell Mol Neurobiol 2020;40:861-78
