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Furthermore, animal studies tend to concentrate on short-term molecular-level effects, whereas human PCOS with IR involves intricate metabolic-reproductive axis dysregulation (Kamada et al., 2022)

It leads to the activation of dishevelled proteins, inhibition of GSK-3 kinase, nuclear accumulation of -catenin and activation of Wnt target genes

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Another study showed the stimulation of C

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Lastly, a wide range of soluble factors [e.g., BDNF and chemokine (C-X-C motif) ligand 1 (CXCL1)] released by astrocytes can have myriad effects on myelination, as found in rodents (Tsai et al., 2002