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TrkB receptors are activated when 7,8-dihydroxyflavone is taken orally, according to a pre-clinical investigation, and improves the cognitive functions in rodents by reducing cortical hippocampal A (Liu et al., 2010)

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Psychopharmacology 232:42614268 Nishi D, Koido Y, Nakaya N, Sone T, Noguchi H, Hamazaki K, Hamazaki T, Matsuoka Y (2012) Fish oil for attenuating posttraumatic stress symptoms among rescue workers after the great East Japan earthquake: a randomized controlled trial