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This ubiquitous free thiol is not only important for antioxidative protection of the plasma membrane and organelles, but it also plays distinct roles in cell cycle regulation and apoptosis 26,27

GPX4 shares the amino acid motif of selenocysteine, glutamine, and tryptophan (catalytic triad) with other glutathione peroxidases

NADH is then used in multiple areas of the body to generate energy

NAC can attenuate neuropathic and inflammatory pain in animal models measuring by hot plate and formalin tests [6, 8, 29, 31], and chronic apical lesion in humans evaluating by the VAS (visual analog scale) pain score [32]

doi: 10.23736/S0391-1977.18.02824-9 194 CharoenngamNHolickMF

All statistical analyses were performed using GraphPad Prism version 8