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AChE inhibitor users required stable doses for 3 + months, and female participants had to be postmenopausal, sterilized, or infertile

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General handling and reconstitution Lyophilized vials are typically reconstituted with sterile water or bacteriostatic diluent immediately prior to use, then handled under aseptic conditions

Pregnant/lactating females, patients on hormone replacement therapy or oral contraceptive pills, bleeding disorders, concomitant use of anticoagulants and any known drug allergy especially to TA, associated medical illness, and history of any other depigmenting treatment in the past 3 months were excluded

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