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In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)

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There is also an overall higher remission rate with clinical trials with combined probiotic and antibiotic treatment (4283%) compared to those using probiotics alone (2048%) in long-term studies (4 months) (Table 4 vs

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