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doi:10.1056/NEJMoa2104983

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particularly inclusion of "among others"... Response: We have replaced this sentence with: While these three components are all directly related to ghrelin, one cannot deny the complex interrelationships between ghrelin and the multitude of other systems beyond simply the typical feeding circuitry of this peptide. Line 365-6: Statement "In addition to this, similar situations that lead to drug relapse also lead to relapse in dieting individuals (Nair et al., 2011)" is confusing

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One important caveat: while GHK-Cu shows promise, direct clinical trials on copper peptides specifically for atopic dermatitis remain limited

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IL-6 is also an inflammatory mediator and a key cytokine of the innate immune system [75]

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Youve made some decent points there

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Creating an effective fitness routine that fits into a busy schedule [41:45]

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