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Since there are known APOE -dependent differences in the gut microbiota in both humans and APOE-TR mice (Tran et al., 2019), L-carnitine metabolism could be impacted and, in turn, affect cerebrovascular function by disturbing normal L-carnitine shuttle function, particularly if other vulnerabilities are present

Disconnect between genes associated with ischemic heart disease and targets of ischemic heart disease treatments

Inclusion criteria included: (I) randomized controlled trial (RCT), (II) with Body Mass Index (BMI) information, (III) exact dose and duration of l-carnitine, acetyl-l-carnitine, and propionyl-l-carnitine

Rezaei et al