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Xue J, et al

In some patients, the immune response leads to viral destruction and downregulation of inflammation, while others generate a severe proinflammatory hypercytokinemia, multisystem inflammation, and shock, with some patients developing respiratory failure requiring mechanical ventilation [52] (Figure 1)

This activation triggers pathways such as PI3K/Akt, TGF-1/p38-MAPK, and NF-B, resulting in endothelial cell apoptosis, inflammation, autophagy, and fibrosis

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DJ-1 -deficient mice exhibit reduced locomotor activity when challenged with amphetamine, along with increased striatal denervation and DA neuron loss induced by MPTP

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