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Description

Oncogene 43 , 884898 (2024)

The usual dosage for initially treating vitamin B12 deficiency in older adults is 1000 micrograms, which can be given as a weekly intramuscular injection, or as a daily oral B12 supplement

CJC-1295 is not for everyone -suitability is assessed at consultation

Maintenance doses are typically 1 mg every 2-3 months for life High-dose oral therapy (1000-2000 micrograms daily) may be effective in selected patients with pernicious anaemia under clinical supervision, as passive diffusion can compensate for absent intrinsic factor, though this is not routine first-line treatment in the UK The water-soluble nature of B12 means that high-dose supplementation carries minimal risk of toxicity , making it a safe option for individuals with confirmed or suspected deficiency

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