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Another novel orally available LDL-C-lowering drug is bempedoic acid, which lowers LDL-C by approximately 2025% by inhibiting the ATP citrate lyase [74] and is now, after the positive CLEAR outcomes trial has demonstrated cardiovascular benefit, also recommended by the recently updated ESC guidelines for the management of dyslipidaemias for patients with statin intolerance or those not at LDL-C target [39, 74]

This latter fact is important because A1 astrocytes are thought to be a primary driver of neurotoxicity and neuron death in Alzheimers Disease

Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet

This medicine is not recommended during pregnancy and breastfeeding unless specifically advised by a healthcare professional due to the lack of specific data

CD117 and cMYC Expression

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