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Indeed, LTC 4 receptor antagonists and Mgst2 knockdown abolished ER stress-triggered oxidative DNA damage, as determined by immunostaining of 8-hydroxy-2-deoxy guanosine (8-OHdG) residues within the nuclear DNA, as well as -H2AX, the marker of nuclear dsDNA breaks (Fig

Salivary miRNA profiles identify children with autism spectrum disorder, correlate with adaptive behavior, and implicate ASD candidate genes involved in neurodevelopment

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Moreover, the GSH-triggered systemic [Ca 2+ ] cyt transmission was dramatically repressed by pretreatment on the petiole of the wounded leaf with the Ca 2+ channel inhibitor LaCl 3 (Fig

Tumor cells and immunosuppressive cells in the microenvironment act synergistically to induce mitochondrial ROS (mtROS) generation, aiding in the establishment of immune tolerance (42)