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2 Pathophysiology of traumatic brain injury In the United States, TBI accounts for around 40% of deaths resulting from acute injuries and stands as the primary cause of death in individuals under the age of 45

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3 Am J Physiol Regul Integr Comp Physiol Characterization of pituitary IGF-I receptors (Fruchtman et al., 2002)Demonstrates des(1-3)IGF-I binds the IGF-I receptor with high affinity but IGF-binding proteins weakly, and is more potent than IGF-I in a receptor-mediated readout &mdash