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Translational barriers and clinical limitations of CSC-targeted therapies A representative summary of clinical trials and approved CSC-targeting agents, including pathway inhibitors, immune therapies, and metabolic modulators, is provided in Table 1

Liraglutide 3.0 mg reduces body weight and improves cardiometabolic risk factors in adults with overweight/obesity: the SCALE obesity and prediabetes randomised trial

doi: 10.1371/journal.pone.0150621, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 203.Sheu J, Tsai M, Erickson SR, Wu C

Free Radic Biol Med 95:323332

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It can be expected that if adjuvants have anti-amyloid, anti-tau, neurochemical, mitochondrial, antioxidant or anti-inflammatory effects [125,140], they may also have the therapeutic potential to moderate the progression of cognitive impairment in AD