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Many autophagic inducers were tested in animal models or have been used in the clinic

Retinoic acid-inducible protein 1 has been shown not only to induce IFN and cytokine production but also to inhibit HBV replication through sensing of the epsilon structure of pgRNA.65 SB 9200, an oral prodrug of the dinucleotide SB 9000, is thought to activate retinoic acid-inducible protein 1 and nucleotide-binding oligomerisation domain-containing protein 2, resulting in IFN-mediated antiviral immune responses in virus-infected cells and decreased serum woodchuck hepatitis virus DNA and surface antigen levels.66 Clinical trials are ongoing

FTO, on the other hand, reverses both m6A and m6Am via oxidation, but has a higher catalytic activity for m6Am (96, 97)

Endogenous kynurenines as targets for drug discovery and development