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1-3 Diagnoses of hyperpigmented lesions of the oral mucosa include physiologic melanin pigmentation, drug-induced skin pigmentation, oral melanocytic nevus, melanoma, black hairy tongue, oral melanoacanthoma, smoker's melanosis, amalgam tattoo, postinflammatory hyperchromia, and Laugier-Hunziker syndrome (pigmentation of the oral mucosa associated with melanonychia)

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Most available data consists of observational reports from weight loss clinics where multiple interventions (caloric restriction, exercise programs, behavioral counseling) are implemented simultaneously, making it impossible to isolate the contribution of lipotropic injections

As of October, 2020 the ICGC repository includes two skin cancer and one melanoma projects ( Supplementary Figure 1 )