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As has been implied [25], circulating glutamine contributed significantly more to de novo glutathione synthesis in the liver (Fig 6E), but was not upregulated in any other organs (S4AS4C Fig)

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
Among them, metabolic modulators, exemplified by metformin, effectively regulate the Treg/Th17 balance of patients with RA through the activation of AMPK and the inhibition of key signaling pathways, such as mTOR, STAT3, and HIF-1, attenuating the inflammatory response and inhibiting osteoclast formation, thereby alleviating disease progression (219)

Ultrasound 24 (4), 417422 (2021)
