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Bibcode:2010BBRC..396...74B

A comparison of lithium and T 3 augmentation following two failed medication treatments for depression: a STAR*D report

Int J Clin Exp Med (2015) 8(7):10491500

[3] In essence, pyridoxines mechanism of action is to restore or maintain levels of PLP, thereby supporting the enzymatic processes that depend on this cofactor

This is because extensive metabolism can lead to the breakdown of the drug before it reaches its target site, reducing its overall bioavailability
