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et al.) Endotext (MDText.com, 2000)

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Some individuals are simply low responders to certain peptides

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[DOI] [PubMed] [Google Scholar] Yue Y.-Z

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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

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