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Previous studies showed that both experimentally induced circulating IGF-1 deficiency [14] and cell-specific disruption of IGF1R signaling in astrocytes [42] impair astrocyte-mediated NVC responses

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Mood Disturbances and Anxiety: The methylation cycle is directly responsible for producing SAMe, which is required to synthesize mood-regulating neurotransmitters

However, high doses or unregulated use of glutathione supplements may affect natural production or interact with certain medications

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