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This study shows that although CD8 + PD-1 + T cells accumulate in MASH livers, anti-PD-1 treatment is ineffective in preclinical models of MASH-induced liver cancer and that anti-PD-1 blockade in patients with HCC leads to worse prognosis, highlighting how metabolic disorders can induce immune dysfunction and inhibit immunotherapy response in liver cancer

This increase was confirmed by both linear regression analysis and repeated measures ANOVA

Clomiphene (supportive, non-peptide): Enhances endogenous testosterone signaling alongside HCG

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For perimenopausal women, timing these medications strategically around periods of worst symptoms may provide relief while minimizing long-term use