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Nanocarrier fabrication and macromolecule drug delivery: challenges and opportunities

Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn .) Link

Caspases play no role in this biochemical cascade

We propose that NADPH and GSSG convey TCA cycle status: decreasing the availability of acetyl-CoAeither from lipid or carbohydrate catabolismdampens NADPH production and disfavors glutathione reduction, with the increased GSSG ultimately rendering the ER lumen more oxidizing and protecting ER homeostasis

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