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Surprisingly, gliotoxin can also induce apoptosis in paclitaxel-resistant ovarian cancer cells via the upregulation of active p63 (TAp63), and it was demonstrated that the pretreatment of ovarian cancer cells with gliotoxin can inhibit the expression of drug-resistant proteins MDR1 and MRP1-3, thus inducing caspase-dependent apoptosis through autophagy after subsequent treatment with paclitaxel [89]

Kaur R, Mehan S, Singh S

doi: 10.1007/s10750-004-2681-5
Aconitase inactivation and oxidative stress have been noted in other neuropsychiatric and neurodegenerative disorders with known mitochondrial involvement, including schizophrenia, 50, 51 Huntington's disease 52 and Parkinson's disease

The Potential Dangers of Glutathione The use of glutathione, especially in high doses, has been linked to several adverse effects

Mechanistic insights into the pharmacological significance of silymarin