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On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed

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Studies have shown that the bioavailability of B12 is three times greater in dairy products than in fish, poultry, and meat

This peripheral restriction is fundamentally different from compounds like Semaglutide (a GLP-1 agonist that acts centrally to reduce appetite) or ghrelin-modulating agents that directly influence hunger hormones

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however, on average 1,000 g/day is recommended