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.,HongY,BoitiA,ValloneDFoulkesNSReactive oxygen species signaling and oxidative stress: Transcriptional regulation and evolution.2024;13(3):312 5

More recently, another study explored NAM supplementation in a golden retriever muscular dystrophy model, demonstrating increased NAD + levels in skeletal muscles and improved skeletal muscle function 266

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Succinate stimulates the renin-angiotensin system through its interaction with endothelial cell GPR91, leading to elevated levels of angiotensin II (Ang II), which promotes vasoconstriction of endothelial cells and inhibits NO production, resulting in endothelial dysfunction [172]

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Abbreviations: ASQ, ages and stages questionnaire