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In this study, we systematically demonstrated that both genetic amplification (exogenous overexpression) and pharmacological induction (endogenous upregulation) of ChaC1 profoundly sensitized hepatocellular carcinoma (HCC) cells to auranofin (AUR) cytotoxicity

J Clin Invest, 133(12) Yang A et al (2024) Regulation of RAS palmitoyltransferases by accessory proteins and S-palmitoylation

MaJZhengYTangWYanWNieHFangJet alDietary polyphenols in lipid metabolism: a role of gut microbiome

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Ferroptosis is a way to regulate CD caused by iron overload and reactive oxygen species (ROS)-dependent lipid peroxides accumulation, with structural changes focused on mitochondria (Shojaie et al., 2020)

The mitochondrial pellet was resuspended in 90 L of 1X TD (49.99 mM Tris base [Research Products International, T60040-5000], 274.13 mM NaCl, 20.12 mM KCl, 13.95 mM Na 2 HPO 4 [Sigma-Aldrich, S5136]) and split between three 1.5 microcentrifuge tubes