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[] The ongoing clinical trials (NCT03618381, NCT04483778, and NCT04897321) investigate EGFR -and B7-H3-targeting CAR-T cell therapy for MPNST

Mitochondria produce large amounts of ROS through the oxidation-reduction reactions carried out in the respiratory chain.2 Evidence indicates that under physiological conditions, ROS may participate in redox signalling, but excessive ROS production may cause oxidative damage to proteins, lipids and DNA, and affect cellular functionality.3 Several studies indicate the role of oxidative stress in the progression of autoimmune thyroid diseases, such as Graves disease.4 ROS are neutralised by the antioxidant enzymes SOD, CAT, and GPx

Shaw, G

Am J Med 123: 711718, 2010

P.RajasekaranS

169 VzquezG.CaballeroA.KokindaJ.HijanoA.SabatR.GamezP
