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Though there was no statistically significant difference in caregiver-rated Social Responsiveness Scale (SRS) in the group as a whole, there was statistically significant benefit in a subgroup of patients between ages 3-5

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A lack of LIFR promotes the nuclear factor B signaling via src homology-2 domain-containing protein tyrosine phosphatase 1, activating the iron-sequestering cytokine lipocalin 2 (LCN2), reducing iron levels, and leading to robust resistance to ferroptosis

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