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Degenerative pathways would dominate, promoting cell death upon neurotrophin binding to p75 NTR through activation of pro-apoptotic JNK-p53-Bax pathway or suppressing Ras/PI3K/Akt activation when conditions of either lacking or deficient Trk signaling or increased p75 NTR expression occur 6

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In addition to their antioxidant and detoxification properties, GSTs participate in the regulation of cell proliferation/apoptosis [4], metabolism of leukotrienes, prostaglandins, and steroids [57], indicative of both enzymatic and non-enzymatic function of GSTs in cellular homeostasis

Muscle wasting: The gut microbiota as a new therapeutic target

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Dennis VA, Dixit S, O'Brien SM, Alvarez X, Pahar B, Philipp MT

10.1002/advs.202405406 78