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The signaling molecule H 2 O 2 oxidizes cysteine 199 (Aslund et al., 2 O 2
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[DOI] [PubMed] [Google Scholar] 209.Zhao G, Souers AJ, Voorbach M, et al
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In Noonans syndrome genetic defects in the PTPN11 gene may affect this pathway and has been implicated in poor growth and poor response to GH therapy, although reports are conflicting (99, 100)
