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For melasma, topical treatment is not optional, it is the anchor of the protocol, a point the published evidence reinforces repeatedly
For many, the process can be highly uncomfortable and unsettling
That's the reality
Dig Dis Sci 43:21312137 Holzbach RT, Marsh M, Olszewski M, Holan K (1973) Cholesterol solubility in bile
C., Kohn, E
Soc Neurosci Abstr 23: 1761
