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64 , S612 (2016)

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For LNPs conjugated to active targeting moieties, such as specific antibodies, affinity-based pull-down isolation methods have emerged as a promising approach to separate protein-coated LNPs from a biological fluid, however this methodology still risks the co-isolation of endogenous EVs due to the potential for the targeting antibodies to dissociate from the LNPs and embed within the contaminating EVs 51,52

-secretase-catalyzed cleavage produces soluble APP and C99, a membrane-bound fragment of APP [50]

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