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Decomposition of lipid peroxides can lead to protein-reactive metabolites, e.g., 4-hydroxynonenal, whereas the oxidation of DNA bases can lead to reactive adenine propenal (Figure 4c,d) [38,47]

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the anti-nociceptive effects of NaBPC157 were evaluated in comparison with aspirin and morphine reference standards in various experimental models of indirect/direct nociception and neurotoxicity: writhing (acetic acid/magnesium sulfate), tail pinching, hot-plate, and capsaicin application