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Response to treatment and monitoring : Most patients notice improvement in fatigue within days to weeks of starting treatment, though neurological symptoms may take several months to resolve and may not fully reverse if long-standing

Vitamin B12 is a water-soluble vitamin, meaning that your body excretes what you dont need in your urine, including any excess consumed via supplements or food

However, it is important to understand the different forms in which B12 can be administered and how often injections should be taken

In particular, the improvement of intestinal wall integrity occurs due to the three main mechanisms: i) increased expression of TJ proteins, ii) decreased levels of pro-inflammatory molecules, and iii) increased intracellular antioxidant potential (Sandoval-Ramrez et al., 2021)

This is the most frequently reported side effect and is typical of any subcutaneous injection

Side effects are common and well-documented: nausea (85% of first-time users), facial flushing, fatigue, and injection site pain